Botulinum toxin injections do not improve freezing of gait in Parkinson disease.
Identifieur interne : 002992 ( Main/Exploration ); précédent : 002991; suivant : 002993Botulinum toxin injections do not improve freezing of gait in Parkinson disease.
Auteurs : Marguerite Wieler [Canada] ; Richard Camicioli ; C Allyson Jones ; W R Wayne MartinSource :
- Neurology [ 1526-632X ] ; 2005.
English descriptors
- KwdEn :
- Aged, Botulinum Toxins, Type A (administration & dosage), Botulinum Toxins, Type A (adverse effects), Cross-Over Studies, Disability Evaluation, Double-Blind Method, Female, Gait Disorders, Neurologic (drug therapy), Gait Disorders, Neurologic (etiology), Gait Disorders, Neurologic (physiopathology), Humans, Male, Middle Aged, Muscle, Skeletal (drug effects), Muscle, Skeletal (physiopathology), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Placebos, Surveys and Questionnaires, Treatment Failure.
- MESH :
- chemical , administration & dosage : Botulinum Toxins, Type A.
- chemical , adverse effects : Botulinum Toxins, Type A.
- complications : Parkinson Disease.
- drug effects : Muscle, Skeletal.
- drug therapy : Gait Disorders, Neurologic, Parkinson Disease.
- etiology : Gait Disorders, Neurologic.
- physiopathology : Gait Disorders, Neurologic, Muscle, Skeletal, Parkinson Disease.
- Aged, Cross-Over Studies, Disability Evaluation, Double-Blind Method, Female, Humans, Male, Middle Aged, Placebos, Surveys and Questionnaires, Treatment Failure.
Abstract
Freezing of gait (FOG) is common in patients with Parkinson disease (PD) and responds poorly to medical treatment. Botulinum toxin A (BTX-A) injections into calf muscles decreased FOG in previous open-label studies. The authors conducted a randomized double-blind placebo-controlled crossover study of BTX-A vs placebo in 12 subjects with PD and FOG. No significant improvement with BTX-A was found using subjective and objective measures.
DOI: 10.1212/01.wnl.0000172930.63669.c8
PubMed: 16116132
Affiliations:
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Le document en format XML
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first="C Allyson" last="Jones">C Allyson Jones</name></author><author><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W R Wayne" last="Martin">W R Wayne Martin</name></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Botulinum Toxins, Type A (administration & dosage)</term><term>Botulinum Toxins, Type A (adverse effects)</term><term>Cross-Over Studies</term><term>Disability Evaluation</term><term>Double-Blind Method</term><term>Female</term><term>Gait Disorders, Neurologic (drug therapy)</term><term>Gait Disorders, Neurologic (etiology)</term><term>Gait Disorders, Neurologic (physiopathology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Muscle, Skeletal (drug effects)</term><term>Muscle, Skeletal (physiopathology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Placebos</term><term>Surveys and Questionnaires</term><term>Treatment Failure</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Botulinum Toxins, Type A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Botulinum Toxins, Type A</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Gait Disorders, Neurologic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Gait Disorders, Neurologic</term><term>Muscle, Skeletal</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cross-Over Studies</term><term>Disability Evaluation</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Placebos</term><term>Surveys and Questionnaires</term><term>Treatment Failure</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Freezing of gait (FOG) is common in patients with Parkinson disease (PD) and responds poorly to medical treatment. Botulinum toxin A (BTX-A) injections into calf muscles decreased FOG in previous open-label studies. The authors conducted a randomized double-blind placebo-controlled crossover study of BTX-A vs placebo in 12 subjects with PD and FOG. No significant improvement with BTX-A was found using subjective and objective measures.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Camicioli, Richard" sort="Camicioli, Richard" uniqKey="Camicioli R" first="Richard" last="Camicioli">Richard Camicioli</name><name sortKey="Jones, C Allyson" sort="Jones, C Allyson" uniqKey="Jones C" first="C Allyson" last="Jones">C Allyson Jones</name><name sortKey="Martin, W R Wayne" sort="Martin, W R Wayne" uniqKey="Martin W" first="W R Wayne" last="Martin">W R Wayne Martin</name></noCountry><country name="Canada"><noRegion><name sortKey="Wieler, Marguerite" sort="Wieler, Marguerite" uniqKey="Wieler M" first="Marguerite" last="Wieler">Marguerite Wieler</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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